Prof. Qiu Zhen





Miniaturized Microendoscope for Molecular Imaging



MEMS based microendoscopes have become important imaging tools for early cancer diagnosis and precise tumor resection. Due to various technical challenges, few microendoscopes have been translated to clinics or applied to human patients. Through synergistic collaborations, we have developed novel MEMS scanner enabled microendoscopic multispectral (visible to NIR) three-dimensional fluorescent imaging system for translational applications, including early cancer detection and staging on colorectal cancer, molecular imaging guided surgical navigation on head and neck cancer. We have miniaturized the imaging system with compact form-factor by integrating micro-optics and micro-scanners, which have been custom-made and mass-produced in the nanofabrication foundry. The metal coating of the scanning mirror provides over 80% high reflectivity over near infra-red range. Both axes of the MEMS scanner could perform large tilting angles. By advanced computational imaging approach, we have achieved real-time cross-sectional imaging in either raster or Lissajous pattern scanning with fast frame rate (> 10 Hz) with large field-of-view (> 600 microns). Advanced real-time mosaicing algorithm has been developed to achieve broader view in milli-meter scale. By utilizing molecular contrast probes conjugated with fluorescence dye, we have successfully demonstrated multi-spectral ex vivo and in vivo imaging on small animal tumor models and human tissue specimens, aimed for both early cancer detection and molecular imaging guided surgical navigation.



Zhen Qiu received the B.S. degree in precision instrumentation and advanced manufacturing from the Department of Precision Instruments, Tsinghua University, Beijing, China, in 2004, and the Ph.D. degree in bio-photonics and biomedical imaging from the Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA, in 2013. He finished his postdoctoral training from the Department of Radiology and Molecular Imaging Program Stanford (MIPS), School of Medicine, Stanford University, CA, USA. He is currently an Assistant Professor with the Department of Biomedical Engineering, Institute for Quantitative Health Science and Engineering (IQ), Michigan State University, East Lansing, MI, USA. His research interests include biomedical optics, micro-opto-electro-mechanical system, multi-modal targeted imaging using novel contrast agents, wearable and implantable medical devices, ultrafast laser applications.



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